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无机砷诱导产生肿瘤的机制被广泛研究。越来越多的证据显示它的致癌性是与表观遗传、尤其是DNA甲基化的改变相关。本文就砷甲基化的代谢过程和产物、砷暴露对DNA甲基化的作用以及砷诱导癌标记基因的研究进展做一论述。
The mechanism of inorganic arsenic-induced tumorigenesis has been extensively studied. There is growing evidence that its oncogenicity is associated with changes in epigenetics, especially DNA methylation. This article reviews the progress of arsenic methylation metabolic processes and products, the role of arsenic exposure in DNA methylation, and the progress of arsenic-induced cancer marker genes.