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目的：探讨血清透明质酸(HA)、层粘连蛋白(LN)及Ⅳ型胶原(col Ⅳ)测定在糖尿病中的意义。方法：采用放射免疫分析法测定90例糖尿病患者及76例健康对照者血清中HA、LN及col Ⅳ 的含量，并初步分析它们在糖尿病中的意义。结果：①糖尿病组血清HA高于对照组(P<0．05)；②糖尿病组血清LN高于对照组(P<0．01)；③血清col Ⅳ在糖尿病组与对照组之间比较无显著性差异(P>0．05)。结论：血清HA及LN的检测对糖尿病及其并发症的诊断具有重要价值。
Objective: To investigate the significance of determination of serum hyaluronic acid (HA), laminin (LN) and type Ⅳ collagen (col Ⅳ) in diabetes mellitus. Methods: Serum levels of HA, LN and col Ⅳ were measured by radioimmunoassay in 90 patients with diabetes mellitus and 76 healthy controls, and their significance in diabetes was analyzed. Results: ① The level of serum HA in diabetic group was higher than that in control group (P <0.05); ② The level of serum LN in diabetic group was higher than that in control group (P <0.01); ③Serum col Ⅳ was no significant difference between diabetic group and control group Significant difference (P> 0.05). Conclusion: The detection of serum HA and LN is of great value in the diagnosis of diabetes mellitus and its complications.