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目的探讨血浆可溶性血管细胞黏附分子-l(sVCAM-1)在小儿川崎病(KD)和败血症中的变化及临床意义。方法2004-01-01—2006-12-31郑州大学第三医院儿科应用ELISA双抗体夹心法,检测小儿川崎病(KD)40例和败血症40例血浆sVCAM-1含量及治疗前后的变化,并以30例健康儿童作为对照组。结果治疗前后KD组的血浆sVCAM-1含量无显著变化[(25.25±4.15)μg/Lvs(24.98±4.89)μg/L,P=0.444],而败血症患儿治疗前后变化显著[(20.64±3.13)μg/Lvs(11.01±3.11)μg/L,P<0.01]。治疗前后KD和败血症患儿的血浆sVCAM-1含量均显著高于对照组[(7.33±1.65)μg/L],且KD组也均显著高于败血症组(P均<0.01)。结论sVCAM-1参与了KD和败血症发病的炎症反应过程,且对KD与败血症的鉴别诊断有一定临床意义。
Objective To investigate the changes and clinical significance of plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) in children with KD and sepsis. Methods The pediatric patients with pediatric Kawasaki disease (KD) in 40 cases and 40 cases of sepsis were enrolled in this study. The levels of sVCAM-1 in plasma and the changes before and after treatment were detected by ELISA in the Pediatrics of Third Hospital of Zhengzhou University from January 2004 to January 2006. 30 healthy children as control group. Results Before and after treatment, there was no significant change in plasma sVCAM-1 level in KD group [(25.25 ± 4.15) μg / L vs (24.98 ± 4.89) μg / L, P = 0.444] ) μg / Lvs (11.01 ± 3.11) μg / L, P <0.01]. The levels of plasma sVCAM-1 in children with KD and sepsis before and after treatment were significantly higher than those in the control group [(7.33 ± 1.65) μg / L], and also significantly higher in the KD group than in the sepsis group (all P <0.01). Conclusion sVCAM-1 is involved in the inflammatory reaction of KD and sepsis, and has certain clinical significance in the differential diagnosis of KD and sepsis.