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奥沙利铂是继顺铂、卡铂之后的第3代铂类抗肿瘤药物,是内科治疗消化道肿瘤的重要药物之一,从20世纪90年代开始应用于临床,并依靠其卓越的疗效奠定了内科治疗结直肠癌的重要位置。N9741试验使FOXFOL4方案成为晚期结直肠癌的一线可选方案~([1,2]),继而一项名为MOSAIC的研究,FOLFOX4方案对比5-FU加甲酰四氢叶酸,也如其研究者的设想一样为早期的Ⅱ、Ⅲ期结肠癌患者带来了明显获益~([3])。对于除结直肠癌的其他恶性肿瘤,奥沙利铂亦显
Oxaliplatin is the third generation of platinum anticancer drugs following cisplatin and carboplatin. It is one of the important medications for medical treatment of gastrointestinal tumors. Since the 1990s, oxaliplatin has been used clinically and relied on its excellent curative effect Lay an important medical treatment of colorectal cancer. The N9741 trial made the FOXFOL4 regimen a first-line alternative to advanced colorectal cancer ~ ([1,2]), followed by a study called MOSAIC that compared the 5-FU plus leucovorin to the FOLFOX4 regimen Like the concept of early stage II and III patients with colon cancer has brought significant benefits ~ ([3]). Oxaliplatin is also indicated for other malignancies other than colorectal cancer