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美国得克萨斯大学西南医学中心的研究人员研制出一种能保护小鼠抵抗肺支原体的“基因组”疫苗.这种疫苗是通过分离能产生抗原性蛋白的基因制备的,这一方法可能是任何病原体疫苗接种的通用方法.具体方法为,用一种酶随机切割病原体的基因组,产生几组完整的基因片段,然后将每组片段克隆进质粒(本小鼠试验应用的是人生长激素质粒),并与微金珠结合.用基因枪将该疫苗射入皮肤细胞,每组基因在此表达并产生病原体蛋白.一些蛋白能诱导较强的免
Researchers at the University of Texas Southwestern Medical Center have developed a “genomic” vaccine that protects mice against Mycoplasma hyopneumoniae, a vaccine that is made by isolating genes that produce antigenic proteins, possibly by any pathogen vaccine The general method of inoculation is to randomly cut the genome of the pathogen with an enzyme to generate several complete sets of gene fragments and then cloned into each plasmid (in this experiment, human growth hormone plasmid is used) Binding with micro-gold beads The vaccine is injected into skin cells using a gene gun where each group of genes is expressed and produces the pathogen protein Some proteins induce strong immunity