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目的探讨子宫Müllerian腺肉瘤伴间质横纹肌样瘤分化的临床病理特征。方法用光镜、组织化学及免疫组化方法观察其病理组织学表现。结果肿瘤由良性上皮成分和肉瘤性间质成分组成,肉瘤成分过度生长。肿瘤细胞弥漫浸润性分布,细胞大,胞质丰富嗜酸性并可见嗜伊红包涵体。免疫表型:vim entin、CK、NF、CD57、CD99、CgA、Syn阳性,SMA散在阳性,而desm in、EMA、CD10、GFAP、MyoD1、Inh ib in-α、HMB45和S-100蛋白阴性。组织化学染色PAS阴性,网状纤维染色显示网状纤维包绕单个或小巢肉瘤性间质细胞。结论子宫腺肉瘤伴间质横纹肌样瘤分化是一种罕见的混合性Müllerian肿瘤,应与子宫内膜间质肉瘤、子宫横纹肌肉瘤和低分化癌等鉴别。
Objective To investigate the clinicopathological features of uterine Müllerian adenosarcoma with interstitial rhabdomyosarcoma. Methods The histopathological changes were observed by light microscopy, histochemistry and immunohistochemistry. Results The tumor consisted of benign epithelial components and sarcomatoid interstitial components, with sarcoma components overgrowing. Tumor cells diffuse diffuse distribution of large cells, cytoplasm rich eosinophilic and visible eosinophilic inclusion bodies. Immunophenotype: vim entin, CK, NF, CD57, CD99, CgA, Syn were positive, SMA was scattered positive, while desm in, EMA, CD10, GFAP, MyoD1, Inh ib in-alpha, HMB45 and S-100 protein were negative. Histochemical staining of PAS was negative, and reticular fiber staining showed reticular fibers surrounding single or small sarcomatoid stromal cells. Conclusions Differentiation of uterine adenosquamous carcinoma with interstitial rhabdomyosarcoma is a rare mixed Müllerian tumor that should be differentiated from endometrial stromal sarcoma, uterine rhabdomyosarcoma and poorly differentiated carcinoma.