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目的探讨水飞蓟宾磷脂复合物(水林佳)对高脂饮食大鼠脂肪肝和动脉硬化造模形成的影响。方法22只SD大鼠随机分为3组,对照组(n=6)普通饮食饲养,模型组(n=8)和干预组(n=8)以高脂饮食+维生素D+丙基硫氧嘧啶造模,干预组同时在饮水中加用水林佳(225 mg.kg-1.d-1),各组大鼠均于实验第16周末处死,常规检测血液生化指标,并观察肝脏和主动脉壁病理改变。结果模型组出现明显的肝脏脂肪变、炎症和坏死,主动脉壁中膜轻度增厚,部分内皮下可见钙化斑,而水林佳干预组肝脏脂肪变和炎症程度较模型组明显改善(P<0.05),且伴血清转氨酶水平显著下降(P<0.01)。然而,水林佳干预组血糖、血脂及主动脉粥样硬化病变情况较模型组无明显改变。结论水林佳能减轻高脂饮食脂肪肝大鼠脂肪性肝炎程度,但无改善糖脂紊乱和动脉硬化作用。
Objective To investigate the effect of silibinin phospholipid complex (Shui Lin Jia) on the formation of fatty liver and atherosclerosis in rats fed high-fat diet. Methods Twenty-two SD rats were randomly divided into three groups: the control group (n = 6), the normal diet group, the model group (n = 8) and the intervention group At the same time, rats in each group were sacrificed at the end of the 16th week. The blood biochemical parameters were routinely measured and the liver and aorta Wall pathological changes. Results The model group showed obvious steatosis, inflammation and necrosis of the liver, slightly thickening of the media in the aortic wall and calcification spots in some of the endothelium, while the degree of hepatic steatosis and inflammation in the Shuilin good intervention group was significantly improved compared with the model group (P <0.05), and the level of serum ALT was significantly decreased (P <0.01). However, the water Lin Jia intervention group, blood glucose, blood lipids and aortic atherosclerosis than the model group did not change significantly. Conclusions Shui Lin Jianeng can reduce the degree of steatohepatitis in fatty liver rats with high-fat diet, but not improve the dyslipidemia and atherosclerosis.