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通过我院１９８８年１月～１９９３年１２月围产儿死亡中出生缺陷的临床病理分析及顺位，探讨高海拔地区（西宁海拔２２６０ｍ）围产儿死亡中出生缺陷的特点。本组围产儿死亡率２０％，共１０３例，其中发现有出生缺陷者２７例，主要为严重的心血管畸形，多数伴有多发畸形；其次为神经系统开放性畸形，消化系统畸形等。分析提示：出生缺陷以心血管畸形为主，明显不同于平原地区，可能与高海拔寒冷、病毒感染频繁、缺氧等因素有关。
Through the clinicopathological and pathological analysis of birth defects in perinatal death from January 1988 to December 1993 in our hospital, we discuss the characteristics of birth defects in perinatal death in high altitude (2260 m above sea level in Xining). The perinatal mortality rate in this group was 20%, a total of 103 cases, of which 27 cases were found to have birth defects, mainly for severe cardiovascular malformations, the majority accompanied by multiple deformities; followed by the nervous system open deformity, digestive system deformity and so on. Analysis suggests that birth defects mainly cardiovascular malformations, significantly different from the plains, may be cold and high altitude, frequent viral infections, hypoxia and other factors.