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目的探讨大骨节病地区儿童与非大骨节病地区儿童内外环境中氟元素水平及其与大骨节病的关系。方法采用氟离子选择电极法测定大骨节病地区与非大骨节地区水、土和粮食中以及大骨节病地区患儿与内、外对照组儿童的尿、发中的氟元素含量。结果①大骨节病地区水中氟含量为(0.24±0.10)mg/L、土中氟含量为(472.94±83.40)mg/kg和小麦中氟含量为(2.04±0.35)mg/kg显著低于非大骨节病地区水中氟含量为(0.26±0.08)mg/L、土中氟含量为(526.60±70.25)mg/kg、小麦中氟含量为(2.33±0.411)mg/kg;②大骨节病组儿童尿氟含量(0.87±0.34)mg/L、发氟含量(7.24±1.36)mg/kg及内对照组尿氟含量(0.92±0.42)mg/L;发氟含量(8.12±1.46)mg/kg显著高于外对照组尿氟含量(0.67±0.27)mg/L;发氟含量(7.24±1.36)mg/kg。结论青海大骨节病儿童外环境氟元素含量偏低,而体内环境偏高,呈现体内、外环境氟元素含量不一致现象。
Objective To investigate the relationship between fluoride levels in children and non-Kashin-Beck disease in children with Kashin-Beck disease in children with Kashin-Beck disease. Methods Fluorine ion-selective electrode method was used to determine the content of fluorine in urine and hair of children with Kashin-Beck disease and non-Kashin-Beck area in water, soil and food and Kashin-Beck disease area. Results (1) The contents of fluoride in water were (0.24 ± 0.10) mg / L, (472.94 ± 83.40) mg / kg in soil and (2.04 ± 0.35) mg / kg in wheat in Kashin- (0.26 ± 0.08) mg / L, F (526.6 ± 70.25) mg / kg in soil and (2.33 ± 0.411) mg / kg in wheat in Kashin- The levels of urinary fluoride (0.87 ± 0.34) mg / L, fluoride (7.24 ± 1.36) mg / kg and the control group were 0.92 ± 0.42 mg / L and 8.12 ± 1.46 mg / kg was significantly higher than that of the control group (0.67 ± 0.27) mg / L; the content of fluoride was (7.24 ± 1.36) mg / kg. Conclusion Children with Kashin-Beck disease in Qinghai Province have a lower level of fluoride in the external environment and a higher body environment, showing inconsistent fluorine content in the body and external environment.