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昆明种小鼠随机分为四组(A、B、C、D),B、C、D三组在孕15天～生后30天内饲以0.2％甲硫嘧啶,同时C和D组分别于生后16～30天和1～15天注射甲状腺素。B组仔鼠在36天龄时呈克汀病样改变:体重及运动量降低,学习能力下降,脑湿重、全脑DNA和核密度低于对照组A。C组基本上同于B组,但DNA和核密度高于B组,低于A组。D组尽管体重和运动量降低,但脑重和学习能力接近于对照组A,明显高于C组。因此生后1～30天内的甲状腺素缺乏可以导致脑发育落后,在整个脑发育临界期内,生后1～15天对小鼠中枢神经系统的发育最为重要。
Kunming mice were randomly divided into four groups (A, B, C, D). Groups B, C and D were fed with 0.2% methithine from 15th day of pregnancy to 30th day of birth, 16 to 30 days after birth and 1 to 15 days of thyroxine injection. In group B, the pups showed cretinism at 36 days of age. The weight and exercise volume were decreased, the learning ability was decreased, the wet weight of brain and the DNA and nuclear density in whole brain were lower than those in control group A Group C was basically the same as group B, but the DNA and nuclear density were higher than those in group B and lower than those in group A. In group D, although the weight and amount of exercise were decreased, the brain weight and learning ability were close to those in control group A and significantly higher than those in group C. Therefore, 1 to 30 days after birth, thyroid hormone deficiency can lead to brain development and backwardness in the critical period of brain development, 1 to 15 days after birth on the development of mouse central nervous system is most important.