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目的分析高强度聚焦超声治疗胰腺癌不同剂量的效果。方法选取2013年2月~2015年2月间的胰腺癌患者56例,将其按照随机数字表法分组,根据超声剂量的高低分为低剂量组和高剂量组,随访1~18个月,对比两组体积消融情况、疼痛缓解率、并发症情况和平均生存期。结果经过治疗,高剂量组体积消融率明显高于低剂量组(P<0.05)。高剂量组疼痛缓解率明显高于低剂量组(P<0.05)。高剂量组并发症发生情况和低剂量组相似(P>0.05)。高剂量组平均生存期跟低剂量组相似(P>0.05)。结论高强度聚焦超声治疗胰腺癌临床效果确切,高功率治疗更有利于缓解患者疼痛,提高体积消融率,值得推广应用。
Objective To analyze the effects of high intensity focused ultrasound on different doses of pancreatic cancer. Methods Fifty-six patients with pancreatic cancer between February 2013 and February 2015 were divided into two groups according to the random number table. According to the level of ultrasound, the patients were divided into low dose group and high dose group. The patients were followed up for 1 to 18 months, The volume ablation, pain relief, complications and mean survival were compared between the two groups. Results After treatment, the volume ablation rate of high-dose group was significantly higher than that of low-dose group (P <0.05). The pain relief rate of high-dose group was significantly higher than that of low-dose group (P <0.05). The incidence of complications in the high-dose group was similar to that in the low-dose group (P> 0.05). The average survival time of high dose group was similar to that of low dose group (P> 0.05). Conclusion High-intensity focused ultrasound is an effective method for the treatment of pancreatic cancer. High-power therapy is more effective in relieving pain and increasing volumetric ablation rate, which is worthy of promotion and application.