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目的探讨延迟结扎脐带对婴儿免疫功能的影响。方法选择深圳市妇幼保健院2015年10月-2016年3月正常分娩的婴儿1000例为研究对象,以随机数字表法分为观察组与对照组,每组500例,对照组为常规结扎脐带(<10 s),观察组延迟结扎脐带(45~60 s),对两组出生时与出生6个月的体液免疫功能、细胞免疫功能变化进行对比。结果观察组出生时的免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)等体液免疫功能与对照组相比,差异无统计学意义(P>0.05);出生6个月时,两组IgM、IgA含量无明显差异(P>0.05),观察组IgG含量较对照组高,差异有统计学意义(P<0.05)。出生时,两组婴儿的CD4~+、CD8~+、CD4~+/CD8~+差异无统计学意义(P>0.05);出生6个月时,观察组的CD4~+、CD8~+、CD4~+/CD8~+与对照组相比差异有统计学意义(P<0.05)。结论延迟结扎脐带可提高婴儿的体液与细胞免疫功能,具有一定临床价值。
Objective To investigate the effect of delayed ligation of umbilical cord on immune function in infants. Methods 1000 cases of infants born in Shenzhen MCH from October 2015 to March 2016 were randomly divided into observation group and control group with 500 cases in each group. The control group was normal ligation of the umbilical cord (<10 s). The observation group delayed ligation of the umbilical cord (45-60 s), and compared the changes of humoral immune function and cellular immunity between the two groups at birth and 6 months after birth. Results Compared with the control group, there was no significant difference in the humoral immune function of immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) in observation group at the time of birth. At 6 months of birth, there was no significant difference in IgM and IgA levels between the two groups (P> 0.05). The IgG level in the observation group was significantly higher than that in the control group (P <0.05). At birth, there were no significant differences in CD4 ~ +, CD8 ~ + and CD4 ~ + / CD8 ~ + between the two groups (P> 0.05) There was significant difference between CD4 ~ + / CD8 ~ + and control group (P <0.05). Conclusion delayed ligation of the umbilical cord can improve the infant’s humoral and cellular immune function, has some clinical value.