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消化道肿瘤包括胃癌的总体治愈率近10年来没有得到显著提高[1],其中肿瘤的转移和复发是治疗失败的主要原因[2]。单纯靠改进手术技巧很难提高手术切除率,降低术后复发、转移率[3]。而胃癌等消化道肿瘤的生长、转移与复发是血管生成依赖的[4],故以肿瘤血管生成的各个环节为靶点,
The overall cure rate of gastrointestinal cancer including gastric cancer has not been significantly increased in the past 10 years [1], of which the metastasis and recurrence of the tumor are the main reasons for the failure [2]. Simply by improving the surgical skills is difficult to improve the surgical resection rate and reduce the recurrence and metastasis rate [3]. Gastric cancer and other gastrointestinal cancer growth, metastasis and recurrence is angiogenesis-dependent [4], so all aspects of tumor angiogenesis as a target,