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目的:研究左旋甲状腺素钠用于治疗亚临床甲状腺功能减退症的临床效果。方法:选取我院于2015年4月-2017年3月收治的128例亚临床甲状腺功能减退症患者,采用随机数字法分为2组,各64例;对照组患者采用中成药六味地黄丸给予治疗,观察组患者则采用左旋甲状腺素钠治疗;治疗干预后对比观察2组患者游离三碘甲状腺原氨酸、游离甲状腺素、促甲状腺素的变化情况;以及不良反应发生率等,不良反应发生率包括恶心呕吐、腹痛腹泻、心悸及多汗等。结果:2组患者治疗后,观察组患者游离三碘甲状腺原氨酸、游离甲状腺素水平则明显高于治疗前,且优于对照组,P<0.05;促甲状腺素水平则低于治疗前,P<0.05,有统计学意义。不良反应发生率则明显低于对照组,P<0.05,有统计学意义。结论:将左旋甲状腺素钠用于亚临床甲状腺功能减退症治疗中,有良好临床效果,可有效调节患者的游离三碘甲状腺原氨酸、游离甲状腺素水平,促进治疗进程,值得用于临床推广。
Objective: To study the clinical effect of levothyroxine in the treatment of subclinical hypothyroidism. Methods: A total of 128 patients with subclinical hypothyroidism admitted to our hospital from April 2015 to March 2017 were randomly divided into 2 groups (64 cases each). The patients in the control group were given Liuweidihuangwan Treatment, the observation group was treated with levothyroxine sodium; after treatment intervention observed in two groups of patients with free triiodothyronine, free thyroxine, thyroid-stimulating hormone changes; and the incidence of adverse reactions, adverse reactions occur Rates include nausea and vomiting, abdominal pain and diarrhea, heart palpitations and hyperhidrosis. Results: After treatment, the levels of free triiodothyronine and free thyroxine in the observation group were significantly higher than those before treatment and better than those in the control group (P <0.05); the levels of thyrotropin were lower than those before treatment P <0.05, with statistical significance. The incidence of adverse reactions was significantly lower than the control group, P <0.05, with statistical significance. CONCLUSIONS: L-Thyroxine sodium is used in the treatment of subclinical hypothyroidism and has good clinical effect, which can effectively regulate the free triiodothyronine and free thyroxine level in patients and promote the progress of treatment, which is worthy of clinical application .