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慢性溃疡性结肠炎(CUC)是一种病因不明的炎性肠病。可能是环境因素中的感染,细菌产物等作用于宿主的免疫系统,由于遗传的易感性使免疫应答的调节出现异常,反馈机制失调,从而激活靶细胞作出持续和明显的免疫反应导致发病。主要症状为腹泻、腹痛、便脓血及粘液。病程长(可持续数月或数年),常反复发作,给病人造成巨大痛苦。严重者如并发肠穿孔、肠出血、常危及病人生命,需紧急手术治疗,晚期可发生肠腔狭窄甚至癌变。据文献报道,CUC的药物治疗目前广泛采用5-氨基水杨酸(5-ASA)或其偶氮衍生物等取代了传统的水杨酸偶氮磺胺吡啶(SASP)。治疗前必须用内镜确定病变的范围,结肠病变不超过结肠脾曲者可采用5-ASA或皮质激素保留灌肠;如病变仅限于远端20cm以内者可采用以上药物的栓剂;全结肠病变
Chronic ulcerative colitis (CUC) is an inflammatory bowel disease of unknown etiology. May be environmental factors in the infection, bacterial products such as the role of the host immune system, due to genetic susceptibility of the immune response abnormalities, feedback mechanism disorders, and thus activate the target cells to make a sustained and obvious immune response leading to the disease. The main symptoms are diarrhea, abdominal pain, purulent blood and mucus. Long duration (sustainable months or years), often repeated attacks, causing great suffering to the patient. Serious cases such as intestinal perforation, intestinal bleeding, often endangering the lives of patients requiring emergency surgery, may occur in advanced intestinal stenosis or even cancer. It has been reported in the literature that the traditional treatment with CUC has replaced the traditional SASP with 5-aminosalicylic acid (5-ASA) or its azo derivative. Endoscopic treatment must be used to determine the scope of the lesion, colon lesions not more than the spleen of the colon can be used 5-ASA or corticosteroid retention enema; if the lesion is limited to the distal 20cm within the above drugs can be used suppositories;