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目的分析Fascin蛋白在人非小细胞肺癌(NSCLC)组织中的表达及与患者临床病理特征的关系。方法选取73例NSCLC手术后组织标本(NSCLC组)及30例癌旁组织标本,采用免疫组化法对两种组织标本进行染色和半定量检测,分析Fascin蛋白在NSCLC组织中的表达及与患者临床病理特征的关系。结果 NSCLC组织中,Fascin蛋白16例强(+),17例(+),18例弱(+),22例(-),阳性率为69.9%;癌旁组26例(-),4例弱(+),阳性率13.3%;NSCLC组织中Fascin蛋白的阳性率显著高于癌旁组织,差异显著(P<0.05)。NSCLC组织中的Fascin蛋白阳性表达与患者的年龄、性别、吸烟史、肿瘤最大径、组织学类型无关(P>0.05);与患者的TNM分期、淋巴结转移、组织学分化程度具有显著的关系(P<0.05)。结论 NSCLC组织中Fascin蛋白高表达,并且与NSCLC的分期、分化及淋巴结转移有关。
Objective To analyze the expression of Fascin protein in human non-small cell lung cancer (NSCLC) and its relationship with clinicopathological features. Methods Seventy-three NSCLC specimens and NSCLC specimens from 30 NSCLC specimens were collected and stained with semi-quantitative immunohistochemical method to detect the expression of Fascin protein in NSCLC tissues. Clinicopathological characteristics of the relationship. Results The positive rate of Fascin protein was 16 (+), 17 (+), 18 weak (+) and 22 (-) in NSCLC tissues, and the positive rate was 69.9% The positive rate of Fascin protein in NSCLC tissues was significantly higher than that in paracancerous tissues (P <0.05). The positive expression of Fascin protein in NSCLC was not related to the patient’s age, sex, smoking history, tumor size and histological type (P> 0.05), but also had a significant relationship with TNM stage, lymph node metastasis and histological differentiation P <0.05). Conclusion Fascin protein is highly expressed in NSCLC tissues, and is related to the staging, differentiation and lymph node metastasis of NSCLC.