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系统性红斑狼疮是一种涉及多系统损害的自身免疫性疾病,其主要并发症及死亡原因之一是狼疮性肾炎。研究表明,IL-17和产IL-17细胞可以浸润肾脏,与其他细胞因子协同作用,引起肾脏局部炎症反应。拮抗IL-17的生物制剂已应用于银屑病、强制性脊柱炎等免疫介导炎症性疾病,但在系统性红斑狼疮及狼疮性肾炎的研究尚少。本文对IL-17与狼疮性肾炎的关系进行综述,探讨IL-17及其抑制剂在狼疮性肾炎治疗的作用及发展前景。
Systemic lupus erythematosus is an autoimmune disease that involves multiple systemic lesions. One of the major complications and causes of death is lupus nephritis. Studies have shown that, IL-17 and IL-17 cells can infiltrate the kidneys, synergistic with other cytokines, causing local inflammatory response in the kidney. Biological agents that antagonize IL-17 have been used in immune-mediated inflammatory diseases such as psoriasis and forced spondylitis, but there is little research on systemic lupus erythematosus and lupus nephritis. This article reviewed the relationship between IL-17 and lupus nephritis, and explored the role and development of IL-17 and its inhibitors in the treatment of lupus nephritis.