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目的:制备壳寡糖接枝布洛芬(COS-g-IBU)纳米粒负载羟基喜树碱(HCPT)纳米粒,并考察其体外释药性能。方法:以1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐(EDC)为偶联剂,制备壳寡糖接枝布洛芬纳米粒(COS-g-IBU NPs)。以COS-gIBU NPs为载体,使用超声振荡技术制备负载HCPT的壳寡糖接枝布洛芬纳米粒(HCPT-COS-g-IBU NPs)。结果:透射电镜照片显示COS-g-IBU NPs和HCPT-COS-g-IBU NPs为球形,平均粒径分别为(116±2)nm和(146±5)nm,测得药物包封率为(79.24±1.18)%,载药量为(3.62±0.05)%,体外药物释放试验表明HCPT-COS-g-IBU NPs具有明显的缓释作用。结论:COS-g-IBU可作为HCPT缓释载体材料。
OBJECTIVE: To prepare COS-g-IBU nanoparticles loaded with hydroxycamptothecin (HCPT) nanoparticles and study their drug release in vitro. METHODS: Chitooligosaccharide-grafted ibuprofen nanoparticles (COS-g-1) were prepared with 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (EDC) IBU NPs). HCPT-loaded chitooligosaccharides grafted with ibuprofen nanoparticles (HCPT-COS-g-IBU NPs) were prepared using COS-gIBU NPs as a carrier. Results: Transmission electron microscope showed that the average particle sizes of COS-g-IBU NPs and HCPT-COS-g-IBU NPs were spherical and the average particle sizes were (116 ± 2) nm and (146 ± 5) nm, respectively. (79.24 ± 1.18)%, drug loading (3.62 ± 0.05)%, in vitro drug release test showed that HCPT-COS-g-IBU NPs has a significant sustained release. Conclusion: COS-g-IBU can be used as HCPT sustained-release carrier material.