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由于最近发现可以从犰狳获得大量的人麻风菌以及建立了从麻风组织中提纯细菌的方法,故有可能发展一种麻风菌苗.为了估计这种提纯的细菌是否有用,首先需要证实在能够应用于人体的适当条件下仍然保存诱发实验动物迟发型超敏反应(DH)的能力,并且这种麻风菌的制剂不会使机体被组织成份所致敏.本文研究了提纯麻风菌各种剂量、途径、佐剂、对豚鼠诱发CMI反应的能力及这种反应的特异性.研究方法:选体重450～600克的豚鼠
It has become possible to develop a leprosy vaccine due to the recent discovery that a large number of people, Leprosy, can be obtained from the armadillo and that a method of purifying bacteria from leprosy tissue has been established.To estimate the usefulness of this purified bacteria, The appropriate conditions for the human body is still stored to induce delayed-type hypersensitivity (DH) in experimental animals, and the preparation of this leprosy will not cause the body to be sensitized by tissue components.In this paper, , Pathways, adjuvants, the ability to induce CMI response in guinea pigs and the specificity of this response.Methods: Guinea pigs weighing 450-600 g