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［目的］探讨细胞免疫功能与大肠癌患者病情变化及手术前后间的关系。［方法］用流式细胞术测定４４例大肠癌患者手术前后５种细胞免疫表型，并与正常对照组进行比较。［结果］大肠癌术前ＣＤ３＋、ＣＤ４＋、ＣＤ５６＋＋１６、ＣＤ３＋／ＣＤ２５＋细胞及ＣＤ４＋／ＣＤ８＋比值明显低于对照组，ＣＤ８＋细胞显著高于正常对照组（Ｐ＜０．０１）；术后 ＣＤ３＋、ＣＤ４＋、ＣＤ５６＋＋１６细胞及ＣＤ４＋／ＣＤ８＋比值虽有回升，高于术前（Ｐ＜０．０１），但仍明显低于对照组（Ｐ＜０．０５，Ｐ＜０．０１），ＣＤ８＋、ＣＤ３＋／ＣＤ２５＋细胞术后基本恢复正常。转移组除ＣＤ８＋外，各项指标均明显低于无转移组（Ｐ＜０．０１）。［结论］检测细胞免疫功能对大肠癌患者的手术治疗、病情判断及预后评估具有重要意义。
[Objective] To investigate the relationship between cellular immune function and the changes of patients with colorectal cancer before and after operation. [Method] The 5 kinds of cellular phenotype of 44 patients with colorectal cancer before and after operation were determined by flow cytometry and compared with the normal control group. [Results] The preoperative CD3 +, CD4 +, CD56 + + 16, CD3 + / CD25 + cells and the ratio of CD4 + / CD8 + in colorectal cancer were significantly lower than those in control group. CD8 + cells were significantly higher than those in normal control group Although the ratio of CD56 + + 16 cells and CD4 + / CD8 + increased, they were significantly higher than those of the control group (P <0.05, P <0.01), while the ratio of CD8 + and CD3 + After the basic return to normal. Except for CD8 +, the indexes in metastasis group were significantly lower than those in non-metastasis group (P <0.01). [Conclusion] The detection of cellular immune function is of great significance for the surgical treatment, disease judgment and prognosis evaluation of patients with colorectal cancer.