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巴黎Andre Guerbet实验室发展了一种新型的水溶性脊髓腔造影剂——P—297,它的渗透性和脂肪溶解度都低,明显的比其他水溶性脊髓腔造影剂减少了惊厥作用。这种造影剂可以完全溶解,配制成含碘40％以上的溶液,而且粘稠度低适合于临床应用。作者对P—297、碘酞葡胺(Conray 60)、重碘酞葡胺(Dimer X)和碘葡酰胺(Amipaque)都制成每毫升含碘280毫克的试剂后,用猴进行了惊厥作用的对比试验。另外,也用与碘酞葡胺相等渗透度的每立升含4.5克的高渗氯化钠溶液,同碘酞葡胺、碘葡酰胺和P—297分别对在猫身上引起的皮质脊髓反射
Paris Andre Guerbet Laboratory has developed a new water-soluble intracavitary contrast agent - P-297, its permeability and fat solubility are low, significantly less than other water-soluble intracavitary contrast agent decreased convulsions. This contrast medium can be completely dissolved, formulated as a solution containing more than 40% iodine, and low viscosity suitable for clinical applications. The authors performed seizures with monkeys after making P-297, Conray 60, Dimer X and Amipaque into each milliliter of reagent containing 280 mg of iodine Comparison test. In addition, cortico-spinal reflexes induced in cats were also treated with Imidomycin, Iodoglutamine and P-297, respectively, in 4.5 g of hypertonic sodium chloride solution per liter with equal permeation to Ipillulard