论文部分内容阅读
Fascap lysin是从海绵中发现的一种海洋天然活性产物,具有抗肿瘤、抗细菌、抗真菌、抗病毒、抗疟疾、抑制胆碱酯酶等多种生物活性。近年来,Fascaplysin被发现能选择性抑制抗肿瘤靶标——细胞周期蛋白依赖性激酶4,因而备受关注。综述Fascaplysin的抗肿瘤机制、全合成及结构改造的研究进展。
Fascap lysin is a marine natural active product found in sponges. It has many biological activities such as anti-tumor, anti-bacterial, anti-fungal, anti-virus, anti-malaria and cholinesterase inhibition. In recent years, Fascaplysin was found to be able to selectively inhibit the anti-tumor target - cyclin-dependent kinase 4, so much attention. The research progress of Fascaplysin anti-tumor mechanism, total synthesis and structural modification were reviewed.