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目的 探讨大肠癌组织中肿瘤坏死因子受体 (TNFR2 )表达的数目与临床病理因素及肿瘤分期间的关系。方法 用免疫组织化学SABC法检测 97例大肠癌组织、81例癌旁组织及 13例正常肠粘膜中TNFR2 的表达。结果 大肠癌组织中TNFR2 表达比癌旁组织及正常组织显著高表达 (P <0 .0 0 1) ,且癌旁组织TNFR2 表达亦显著高于正常组织 (P <0 .0 5 )。在大肠癌组织中 ,TNFR2 表达与肿瘤分化程度和浆膜浸润无关 (r =- 0 .0 91,P =0 .44 3;r =0 .10 ,P =0 .396 ) ,而与淋巴结转移呈负相关 (r =- 0 .313,P =0 .0 0 7) ,即肿瘤有淋巴结转移时TNF2 表达低。同时 ,DukeA期和B期患者TNFR2 表达显著高于DukeC期 (P <0 .0 0 1)。结论 TNFR2 检测对判断大肠癌恶性程度 ,预测肿瘤淋巴结转移趋势及肿瘤分期有重要价值
Objective To investigate the relationship between the number of tumor necrosis factor receptor (TNFR2) expression in colorectal cancer tissues and clinicopathological factors and tumors. Methods Immunohistochemistry SABC method was used to detect the expression of TNFR2 in 97 cases of colorectal carcinoma, 81 cases of paracancerous tissue and 13 cases of normal intestinal mucosa. Results The expression of TNFR2 in colorectal cancer tissues was significantly higher than that in adjacent tissues and normal tissues (P < 0.01). The expression of TNFR2 in adjacent tissues was also significantly higher than that in normal tissues (P <0.05). In colorectal cancer, TNFR2 expression was not associated with tumor differentiation and plasma membrane infiltration (r = -0.991, P = 0.43; r = 0.10, P = 0.396), but with lymph node metastasis. There was a negative correlation (r = -0.313, P = 0.007), indicating that TNF2 expression was low in tumors with lymph node metastases. At the same time, TNFR2 expression was significantly higher in Duke A and B patients than in Duke C (P < 0.01). Conclusion The detection of TNFR2 has important value in judging the malignant degree of colorectal cancer and predicting the lymph node metastasis and tumor staging.