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目的 探讨儿童肥胖所至动脉粥样硬化 (AS)的早期报警指标。方法 对 32例中重度肥胖及 2 0例健康正常体重儿童内皮素 (ET)及氧化低密度脂蛋白 (OX -LDL)进行测定。结果 肥胖组ET及OX -LDL值分别高于对照组 ,P均 <0 0 1;肥胖组收缩压及舒张压均大于对照组 ,但P均 >0 0 5。其中 10例肥胖儿童经 6周综合减肥治疗 ,自身对比体重下降 ,P <0 0 1;ET水平降低 ,P <0 0 5 ;OX -LDL水平下降 ,P <0 0 1。结论 肥胖症儿童血ET与OX -LDL增高并随体重减低而减少 ;ET可作为早期AS的示警指标
Objective To investigate the early warning signs of atherosclerosis (AS) in childhood obesity. Methods The levels of endothelin (ET) and oxidized low density lipoprotein (OX-LDL) in 32 cases of moderate and severe obesity and 20 normal healthy children were measured. Results The values of ET and OX-LDL in obese group were significantly higher than those in control group (P <0.01). The systolic and diastolic blood pressures in obese group were higher than those in control group, but both were> 0.05. Among them, 10 cases of obese children underwent weight-loss therapy after 6 weeks, their body weight decreased, P <0.01; ET level decreased, P <0 05; OX-LDL level decreased, P <0.01. Conclusion The levels of ET and OX-LDL in children with obesity are increased and decrease with weight reduction. ET can be used as an indicator of early AS