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目的分析脓毒症相关性脑病(SAE)的危险因素。方法选取2012—2013年深圳市中医院收治的脓毒症患者61例,根据SAE发生情况分为SAE组23和非SAE组38例。比较两组患者血清乳酸、S100蛋白、神经元特异性希醇化酶(NSE)、ALT、AST水平及急性生理学与慢性健康状况评分(APACHEⅡ评分),并分析SAE的危险因素。结果两组患者血清乳酸、ALT水平比较,差异无统计学意义(P>0.05);SAE组患者血清S100蛋白、NSE、AST水平及APACHEⅡ评分均高于非SAE组(P<0.05)。多因素logistic回归分析结果显示,血清NSE、AST水平是SAE的独立危险因素(P<0.05)。结论血清NSE、AST水平升高是SAE的独立危险因素。
Objective To analyze the risk factors of sepsis-associated encephalopathy (SAE). Methods Seventy-one patients with sepsis admitted in Shenzhen Hospital of Traditional Chinese Medicine from 2012 to 2013 were divided into SAE group (23 cases) and non-SAE group (38 cases) according to the occurrence of SAE. The levels of serum lactic acid, S100 protein, neuron specific phospholipase (NSE), ALT and AST, and acute physiology and chronic health status score (APACHEⅡ) were compared between the two groups. The risk factors of SAE were analyzed. Results There was no significant difference in serum lactic acid and ALT between the two groups (P> 0.05). Serum levels of S100 protein, NSE, AST and APACHEⅡ in SAE group were significantly higher than those in non-SAE group (P <0.05). Multivariate logistic regression analysis showed that serum NSE and AST levels were independent risk factors for SAE (P <0.05). Conclusion Serum NSE and AST levels are independent risk factors of SAE.