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每日鼻内喷雾LHRH类似物可能为妇女提供一种安全可靠的新的避孕方法,长期应用LHRH显效剂可引起抑制排卵。Schally等提出了LHRH显效剂未抑制雌激素的分泌,因而可能限制其排卵抑制剂的使用。但作者在长期应用LHRH显效剂D-ser(TBU)~6-EA~(10)-LHRH期间,多数妇女子宫有轻度月经样出血,表明雌二醇(E_2)水平可达到滤泡早期至中期的水平。本文研究12例规则月经妇女(年龄为22～37岁,平均29.6岁),从月经来潮的第3天起,每日鼻腔喷雾LHRH显效剂D-ser (TBU)~6-EA~(10)-LHRH(其中5例给予400μg/日,7例600μg/日),连续喷雾13～55周。临床记录基础体温,定期测定血清雌二醇(E_2)和孕酮(P)水平来监测治疗情况。给药78～380天后,进行诊刮,用Van Giesson,HE和糖原染色,作组织学观察。
Daily nasal spray of LHRH analogues may provide women with a safe and reliable new method of contraception, long-term use of LHRH effective agent can cause ovulation inhibition. Schally et al. Proposed that LHRH agonists do not inhibit the secretion of estrogen, which may limit the use of ovulation inhibitors. However, during the long-term application of LHRH marker D-ser (TBU) ~ 6-EA ~ (10) -LHRH, most women had mild menstrual hemorrhage in the uterus, indicating that estradiol (E2) Mid-term level. In this paper, 12 regular menstruating women (aged from 22 to 37 years old, average 29.6 years old) were studied. From day 3 of menstrual cramps, daily nasal spray D-ser (TBU) ~ 6-EA ~ -LHRH (5 cases given 400μg / day, 7 cases 600μg / day), continuous spray for 13 to 55 weeks. Clinical records of basal body temperature, regular determination of serum estradiol (E2) and progesterone (P) levels to monitor the treatment. After 78 to 380 days of administration, a curettage was performed and stained with Van Giesson, HE and glycogen for histological observation.