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【背景】在JUPITER一级预防试验中,他汀类治疗增加糖尿病发生风险的发现使其在已经有糖尿病高危因素的患者中应用受到限制,例如那些空腹血糖受损、代谢综合征、严重肥胖或糖化血红蛋白水平升高者。然而,研究者提到在这些具有高危因素患者以及整个研究队列中,他汀类药物治疗的收益多于致糖尿病风险,应该使内科医生安心使用他汀类药物进行一级预防以减少心肌梗死、中风和心血管死亡。该研究于2012年8月11日发表在《Lancet》杂志。
Background In the JUPITER primary prevention trial, the finding that statin therapy increases the risk of developing diabetes mellitus limits its use in patients already at risk for diabetes, such as impaired fasting glucose, metabolic syndrome, severe obesity, or glycation Hemoglobin levels are elevated. However, the researchers note that statin therapy outweighed the risk of diabetes in these high-risk patients and in the entire study cohort, physicians should be relieved to use statins for primary prevention to reduce MI, stroke and Cardiovascular death. The study was published in Lancet magazine on August 11, 2012.