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目的通过调查,对医院采用质子泵抑制剂治疗慢性消化性溃疡的作用进行分析,为质子泵抑制剂合理使用提供指导与建议。方法从质子泵抑制剂使用频率、患者性别年龄、使用剂量、处方合理性和不良反应等方面展开调查。结果质子泵抑制剂中泮托拉唑和奥美拉唑的用量占前二位,而泰美尼克肠溶片的DUI值达到1.68。中年慢性消化性溃疡病人用量比例达53.73%,处方内容不合理率为3.6%。质子泵抑制剂不良反应集中在消化系统和血液系统,变态反应以及酸反跳较明显。结论质子泵抑制剂存在一定不良反应,应进一步重视该类药物对慢性消化性溃疡使用的合理性,在有效治疗的同时,减少其不良反应。
Objective To investigate the role of proton pump inhibitors in the treatment of chronic peptic ulcer in hospitals and provide guidance and suggestions for the rational use of proton pump inhibitors. Methods The frequency of proton pump inhibitor use, patient’s sex and age, dosage, prescription rationality and adverse reactions were investigated. Results Proton pump inhibitors were the first two in the dosage of pantoprazole and omeprazole, while the DUI value of the trimethoprim enteric coated tablets reached 1.68. The proportion of middle-aged patients with chronic peptic ulcer dosage reached 53.73%, prescription content unjustified rate of 3.6%. Adverse reactions to proton pump inhibitors concentrated in the digestive system and the blood system, allergic reactions and acid rebound more obvious. Conclusion Proton pump inhibitors have some adverse reactions. We should pay more attention to the rationality of these drugs on the use of chronic peptic ulcer, and treat them effectively while reducing their adverse reactions.