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目的探讨双歧三联活菌胶囊对结肠癌术后化疗相关性腹泻患者肠黏膜通透性的影响及疗效观察。方法选取70例结肠癌术后行辅助化疗发生化疗相关性腹泻患者,随机分为观察组和对照组,每组35例。两组患者均予以口服蒙脱石散、静脉补液或口服补液和纠正水电解质酸碱平衡紊乱等常规治疗。观察组患者加用双歧三联活菌胶囊420 mg/次,3次/d,温开水溶解后口服。观察两组患者治疗前和治疗72 h后血清二胺氧化酶(DAO)和肿瘤坏死因子-α(TNF-α)水平的变化,并比较临床疗效及药物不良反应。结果治疗72 h后,两组患者DAO和TNF-α水平均有不同程度下降(P<0.05或P<0.01),且观察组下降程度较对照组更明显(P<0.05);同时观察组患者临床总有效率(94.29%)明显高于对照组(74.29%)(χ2=5.29,P<0.05),两组患者治疗期间无明显的药物不良反应。结论双歧三联活菌胶囊用于治疗结肠癌术后化疗相关性腹泻具有较好的疗效及安全性,能降低血清DAO和TNF-α水平,具有降低肠黏膜的通透性功能。
Objective To investigate the effect of bifidus triplex live capsule on intestinal mucosal permeability in patients with postoperative chemotherapy-associated diarrhea of colon cancer and its therapeutic effect. Methods Seventy patients with colorectal cancer who underwent adjuvant chemotherapy after chemotherapy for chemotherapy-related diarrhea were randomly divided into observation group and control group with 35 cases in each group. Two groups of patients were given oral montmorillonite powder, intravenous rehydration or oral rehydration and correct water and electrolyte acid-base balance disorders and other conventional treatment. Observation group patients with bifidobacterium triple viable capsule 420 mg / time, 3 times / d, dissolved in warm water after oral administration. The levels of serum diamine oxidase (DAO) and tumor necrosis factor-α (TNF-α) were observed before treatment and 72 h after treatment in both groups. The clinical efficacy and adverse drug reactions were compared. Results After 72 h of treatment, the levels of DAO and TNF-α in both groups decreased to some extent (P <0.05 or P <0.01), and the degree of decrease in the observation group was more significant than that in the control group (P <0.05) The total clinical effective rate (94.29%) was significantly higher than that of the control group (74.29%) (χ2 = 5.29, P <0.05). There was no obvious adverse drug reaction during the treatment in both groups. Conclusion Bifid triple viable capsule for the treatment of postoperative chemotherapy-related diarrhea colon cancer has good efficacy and safety, can reduce serum levels of DAO and TNF-α, with a decrease in the permeability of the intestinal mucosa.