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目的 探讨用腹腔热灌注化疗 (IPHP)方法 ,预防胃癌根治术后腹腔内复发及转移。方法 18例胃癌患者行规范根治术后早期用氟尿嘧啶 (5—FU)和丝裂霉素 (MMC)行腹腔内连续热灌注化疗 ,并观察患者肝、肾功能、体温、血细胞计数改变及其生存质量等情况。结果 灌注前后肝、肾功能正常 ;患者体温升高 (38℃左右 )持续10 .9± 3.1天后恢复正常 ;红、白细胞计数在灌注后第 2周略下降 (P >0 .0 5 ,与术前比较 ) ,而血小板计数则下降明显 (P <0 .0 5 ) ,至第 3周恢复至术前水平 (P >0 .0 5 )。随访 2年 ,18例患者均未发现肿瘤复发和转移者。结论 该疗法对胃癌术后腹腔内复发和转移的防治效果较好。
Objective To explore the use of intraperitoneal hyperthermic perfusion chemotherapy (IPHP) to prevent intra-abdominal recurrence and metastasis after radical gastrectomy. Methods Eighteen patients with gastric cancer were treated with 5-fluorouracil (5-FU) and mitomycin C (MMC) in the early stage after routine radical hyperthermia. The changes of liver and kidney function, body temperature, blood cell count and survival were observed. Quality and other situations. Results The liver and renal function were normal before and after perfusion; the patient’s body temperature (about 38°C) returned to normal after 10.9±3.1 days; the red and white blood cell counts decreased slightly at 2 weeks after perfusion (P > 0.05). Before comparison, platelet counts decreased significantly (P <0.05) and returned to preoperative levels in the third week (P > 0.05). After 2 years of follow-up, no recurrence or metastasis was found in any of the 18 patients. Conclusion The therapy has good effect on prevention and treatment of intra-abdominal recurrence and metastasis of gastric cancer.