论文部分内容阅读
目的:分析无明显感染的肝硬化患者各种急性时相蛋白水平与Child-Pugh分级的关系及临床意义。方法:采用全自动速率散射比浊法对58例无明显感染的肝硬化患者和48例非肝硬化患者进行4种急性时相蛋白犤C-反应蛋白、α1-酸性糖蛋白、铜蓝蛋白和触珠蛋白犦的检测,并与Child-Pugh分级等指标行单因素直线相关及多元逐步回归分析。结果:与对照组比较,肝硬化患者的C-反应蛋白水平升高,α1-酸性糖蛋白、触珠蛋白水平明显下降。α1-酸性糖蛋白、触珠蛋白和铜蓝蛋白水平随Child-Pugh分级的增高而逐步下降,α1-酸性糖蛋白、触珠蛋白及铜蓝蛋白与Child-Pugh分级呈明显相关,相关系数r分别为:-0.42、-0.42和-0.37,均为P<0.05。4项急性时相蛋白与其他生化指标的相关检验结果:4项急性时相蛋白与白蛋白无相关,α1-酸性糖蛋白与总胆红素、凝血酶原时间相关,触珠蛋白与凝血酶原时间、载脂蛋白B相关,铜蓝蛋白与载脂蛋白A相关,多因素逐步回归分析显示Child-Pugh分级与α1-酸性糖蛋白、触珠蛋白密切相关。结论:肝硬化患者的C-反应蛋白水平升高,α1-酸性糖蛋白、触珠蛋白水平明显下降,铜蓝蛋白在肝损伤程度较轻时升高,肝损伤严重时呈下降趋势。在无明显继发感染的前提下,酒精性及肝炎后肝硬化患者α1-酸性糖蛋白、触珠蛋白和铜蓝蛋
OBJECTIVE: To analyze the relationship between acute phase protein levels and Child-Pugh classification in cirrhotic patients without obvious infection and its clinical significance. Methods: A total of 58 patients with cirrhosis without cirrhosis and 48 patients with non-cirrhosis were enrolled in this study. Four acute phase proteins, C-reactive protein, α1-acid glycoprotein, ceruloplasmin and Haptoglobin 犦 detection, and Child-Pugh grading and other indicators of single-factor linear regression and multiple stepwise regression analysis. Results: Compared with the control group, patients with cirrhosis increased C-reactive protein levels, α1-acid glycoprotein, haptoglobin levels decreased significantly. The levels of α1-acid glycoprotein, haptoglobin and ceruloplasmin decreased gradually with the increase of Child-Pugh classification. The levels of α1-acid glycoprotein, haptoglobin and ceruloplasmin were significantly correlated with Child-Pugh classification. The correlation coefficient r Respectively: -0.42, -0.42 and -0.37, all P <0.05.4 Acute phase protein and other biochemical indicators test results: 4 acute phase protein and albumin no correlation, α1-acid glycoprotein With total bilirubin, prothrombin time, haptoglobin and prothrombin time, apolipoprotein B related to ceruloplasmin and apolipoprotein A related to multi-factor stepwise regression analysis showed Child-Pugh grading and α1- Acid glycoprotein, haptoglobin is closely related. CONCLUSION: C-reactive protein is elevated in patients with cirrhosis, α1-acid glycoprotein and haptoglobin levels are significantly decreased, and ceruloplasmin is increased when liver damage is mild, and when liver damage is severe, it is decreased. In the absence of significant secondary infection under the premise of alcohol and hepatitis cirrhosis in patients with α1-acid glycoprotein, haptoglobin and copper blue egg