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硝苯啶(100nmol·L(?))或无细胞外钙抑制内皮素-1(ET-1)收缩大鼠胸主动脉80以上。ET-1(20 nmol·L~(-1);15,25min)增加血管环腺苷酸(cAMP)含量,该作用被咪唑二酮(100μmol·L~(-1))增强。ET-1还能增强福斯科林的增加cAMP作用。本文证明ET-1收缩大鼠胸主动脉至少涉及两种信息转导机制,即开放硝苯啶敏感性钙通道和增加cAMP。
Nifedipine (100 nmol·L (?)) Or no extracellular calcium inhibited endothelin-1 (ET-1) contraction in rat aorta over 80. ET-1 (20 nmol·L -1; 15, 25 min) increased the content of cAMP in the vascular rings, which was enhanced by imidazole dione (100 μmol·L -1). ET-1 also enhances the effect of forskolin on cAMP. This paper demonstrates that ET-1 contraction of the thoracic aorta involves at least two mechanisms of information transduction: opening of nifedipine-sensitive calcium channels and increasing cAMP.