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糖尿病患者的胃分泌有减低倾向,而萎缩性胃炎的发生率则有增加。估计有半数患者胃酸的产生减少,1/3以上的患者无胃酸,而且有17%的糖尿病患者发生真性胃酸缺乏。胃酸分泌减少被归因于迷走神经受累,后者为糖尿病内脏神经病变的表现之一。从糖尿病患者的胃活检材料中,细胞学检查证实萎缩性胃炎的发生率较高,壁细胞抗体的存在是萎缩性胃炎发生的主要原因。因此,在理论上,糖尿病患者的溃疡病发生率应当较低。糖尿病患者溃疡病的发生率相对较低。在128,000例糖尿病患者中,胃一十二指肠溃疡的发生率<1.3%,而统计提示溃疡病占总人口的5～12%,这大大地超过了糖尿病患者中溃疡病的发病率。特别是幼年胰岛素依赖型糖尿病,胃分泌有受抑制的倾
Gastric secretion in diabetic patients tends to decrease, while the incidence of atrophic gastritis increases. Half of the patients are estimated to have reduced gastric acid production, more than one-third have no stomach acid, and 17% have true acid-deficiency. Decreased gastric acid secretion is attributed to vagal involvement, which is one of the manifestations of diabetic visceral neuropathy. From diabetic gastric biopsy material, cytological examination confirmed a higher incidence of atrophic gastritis, parietal cell antibody is the main cause of atrophic gastritis. Therefore, in theory, the incidence of ulcer disease in diabetic patients should be low. The incidence of diabetic ulcer disease is relatively low. In 128,000 diabetic patients, the incidence of gastric-duodenal ulcer was <1.3%, and statistics suggest that ulcer disease accounts for 5-12% of the total population, greatly exceeding the incidence of ulcer disease in diabetic patients. In particular, insulin-dependent juvenile diabetes, gastric secretion have inhibited dumping