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目的探讨ER、PR、Her-2、nm23、MDR、LRP及ki-67蛋白表达在新疆维、汉民族乳腺癌患者间的异同。方法维吾尔族和汉族乳腺癌患者按发病时的年龄及肿瘤分期进行1∶1配对,共收集83对病例,采用免疫组化二步法分别检测ER、PR、Her-2、nm23、MDR、LRP及ki-67蛋白在两民族乳腺癌患者的表达情况并进行对比分析。结果维吾尔族乳腺癌患者ER、PR、Her-2、nm23、MDR、LRP及ki-67阳性表达率分别为63.9%、55.4%、28.9%、93.3%、3.6%、44.4%、65.1%,汉族乳腺癌患者阳性表达率分别为61.4%、62.7%、39.8%、97.6%、7.5%、46.5%、76.7%,两组阳性表达率差异均无统计学意义(P=0.724、0.330、0.139、0.277、0.496、0.438、0.061)。维吾尔族和汉族三阴性乳腺癌[ER(-),PR(-),Her-2(-)]的分布差异无统计学意义(χ2=0.182,P=0.669)。结论新疆维、汉民族乳腺癌患者ER、PR、Her-2、nm23、MDR、LRP及ki-67蛋白表达不存在民族差异。
Objective To investigate the similarities and differences of ER, PR, Her-2, nm23, MDR, LRP and ki-67 protein in Xinjiang Uygur and Han nationality breast cancer patients. Methods Uygur and Han women with breast cancer were matched by 1: 1 age and tumor stage according to the age of onset. A total of 83 pairs of cases were collected. The expressions of ER, PR, Her-2, nm23, MDR, LRP And ki-67 protein expression in two ethnic breast cancer patients and comparative analysis. Results The positive rates of ER, PR, Her-2, nm23, MDR, LRP and ki-67 in Uighur women with breast cancer were 63.9%, 55.4%, 28.9%, 93.3%, 3.6%, 44.4% and 65.1% The positive rate of breast cancer patients was 61.4%, 62.7%, 39.8%, 97.6%, 7.5%, 46.5%, 76.7% respectively. There was no significant difference between the two groups (P = 0.724,0.330,0.139,0.277 , 0.496, 0.438, 0.061). The distribution of ER (-), PR (-) and Her-2 (-) in Uygur and Han tri-negative breast cancer showed no significant difference (χ2 = 0.182, P = 0.669). Conclusion There are no ethnic differences in the expression of ER, PR, Her-2, nm23, MDR, LRP and ki-67 in breast cancer patients of Uygur and Han ethnic groups in Xinjiang.