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背景 新生儿同种免疫中性粒细胞减少症(ANN)是由于母亲同种抗体与胎儿粒细胞上所遗传父亲的抗原发生作用而产生了人类嗜中性粒细胞抗体(HNA),该抗体在一半的ANN病例中发现,在其余的病例中特异性抗体没有确定。设计与方法 这里报告了一例由于中性粒细胞减少而导致的新生儿脐炎,使用流动血细胞计数和PCR分析ANN的病因,用淋巴细胞毒试验(LCT),抗人球-LCT和混合被动凝集试验对患儿及母亲血清与中性粒细胞、淋巴细胞和血小板进行检测。结果 母亲血清与
BACKGROUND Neonatal alloimmune neutropenia (ANN) is a human neutrophil antibody (HNA) produced by the interaction of a maternal alloantibody with the antigen of a father inherited on fetal granulocytes, In half of the ANN cases, no specific antibodies were identified in the remaining cases. Design and Methods An example of neonatal omphalitis due to neutropenia was reported here, the etiology of the ANN was analyzed using flow cytometry and PCR, lymphocyte cytotoxicity test (LCT), anti-human-LCT and mixed passive agglutination Test of children and mothers serum and neutrophils, lymphocytes and platelets were detected. Results maternal serum and