Defining a critical period in calvarial development for Hedgehog pathway antagonist-induced frontal

• 作 者: Yuanjing Jiang Shixian Zhang C
• 机 构: DepartmentofOralandMaxillofacialSurgery,InstituteofStomatology,SchoolandHospitalofStomatology,Depart
• 出 处: 国际口腔科学杂志:英文版
• 发表日期: 2019年1期
• 关键词: GDC-0449 was determined PRIMORDIUM was REDUCED
• 基金项目: the National Natural Science Foundation of China(31070838).

The Hedgehog(Hh)signalling pathway is essential for cellular proliferation and differentiation during embryonic development.Gain and loss of function of Hh signalling are known to result in an array of craniofacial malformations.To determine the critical