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目的：研究采用尿激酶治疗急性心肌梗死时对左室重构和心功能的影响，方法：８例急性心肌梗死病人在常规疗法基础上加用尿激酶４８万Ｕ静脉缓推，继而４８万Ｕ置于葡萄糖液２５０ｍＬ中２ｈ内静脉滴注完毕，次日起改用肝素１万Ｕ／ｄ×３ｄ，然后以阿司匹林５０ｍｇ，ｐｏ，ｑｄ治疗为溶栓组。另设９例相似病例采用与溶栓组相同的常规疗法。２组治疗２ｗｋ，４ｗｋ各测１次超声心动图，将２ｗｋ时测得的左室节段长度及心功能测定值作为基础水平，４ｗｋ时测定值与其比较。结果：左室前段增加率在溶栓组明显低于对照组（Ｐ＜０．０５）。结论：溶栓组的左室重构变化程度低于对照组，且左室重构变化率与心功能变化率是一致的。
Objective: To study the effect of urokinase on left ventricular remodeling and cardiac function in patients with acute myocardial infarction.Methods: Eight patients with acute myocardial infarction were treated with 480,000 U of urokinase, followed by 480,000 U Placed in 250mL of glucose solution within 2h intravenous infusion completed the next day with heparin 10,000 U / d × 3d, and then aspirin 50mg, po, qd treatment for the thrombolytic group. Another 9 cases of similar cases with thrombolytic group the same routine therapy. 2 groups were treated 2wk, 4wk each measured 1 echocardiography, measured at 2wk the length of the left ventricular segment and cardiac function measured value as the basic level, 4wk measured values compared with it. Results: The rate of increase in the anterior segment of the left ventricle in the thrombolytic group was significantly lower than that in the control group (P <0.05). Conclusion: The changes of left ventricular remodeling in thrombolytic group are lower than those in control group, and the rates of left ventricular remodeling and cardiac function change are consistent.