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本文作者在肠肝胆汁酸盐循环中断(实验A)和恢复(实验B)后,研究了外加弱电场(1.5～3V,30～60μA)对原位鼠肝脏胆盐分泌的影响。在实验A中,外加电场后3小时,将胆汁酸盐示踪物一次性注入(~(14)C—TC。~(14)C—CA、或~(14)C—DCA)。在实验B中,在外加电场后150分钟直到实验结束这段时间内以每小时36μmoles的速度输注TD或CA。在外加电场后170分钟注射一次性剂量(~(14)C—TC和~(14)C—CA)。在两个实验中对肝牛磺酸池均做了预先标记。外加电场使~(14)C—TC延迟分泌进入胆汁。60μA比30μA的电场造成的
The authors studied the effects of a weak electric field (1.5-3 V, 30-60 μA) on the bile salt secretion in the livers of rats after the intestinal bile acid circulation was interrupted (experiment A) and recovery (experiment B). In Experiment A, bile acid tracer was infused (~ (14) C-TC. ~ (14) C-CA, or ~ (14) C-DCA) three hours after the application of the electric field. In Experiment B, TD or CA was infused at a rate of 36 μmoles per hour for a period of 150 minutes after the application of the electric field until the end of the experiment. One-time doses (~ (14) C-TC and ~ (14) C-CA) were injected 170 minutes after application of the electric field. Liver taurine pools were pre-labeled in both experiments. An additional electric field delays the secretion of ~ (14) C-TC into the bile. 60μA than 30μA caused by the electric field