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近年来用原位核酸杂交和套式聚合酶反应等技术,从各型克山病心肌标本中均发现有柯萨奇B组(CBV)病毒RNA的存在,其阳性率从61.5%到90.0%不等。证明很多克山病病人确有肠道感染,重新提出重视肠道病毒,特别是柯萨奇B组病毒感染在克山病发病中的作用。 作者对克山病非病区——长春地区近年来柯萨奇病毒感染引起的心肌炎给予特别关注。对1992~1996年临床拟诊为急性病毒性心肌炎患者进行了CBV特异性IgM抗体的检验,结果报告如下。
In recent years, with in situ nucleic acid hybridization and nested polymerase chain reaction and other techniques, the presence of coxsackie B (CBV) viral RNA was found in all kinds of Keshan myocardial samples, with the positive rate ranging from 61.5% to 90.0% Do not wait. Proves that many Keshan disease patients do have intestinal infections, re-put emphasis on enterovirus, especially Coxsackie B virus infection in the pathogenesis of Keshan disease. The authors give special attention to myocarditis caused by Coxsackie virus infection in Keshan disease-Changchun area in recent years. CBV-specific IgM antibodies were tested in patients with acute viral myocarditis who were clinically diagnosed in 1992-1996. The results are reported below.