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自从 Hench 等(1949)应用 ACTH 和肾上腺皮质激素治疗类风湿性关节炎获得疗效后,三十多年来临床各科应用皮质激素逐渐广泛。50年代后期开始用于治疗脑水肿取得显著的效果。其抗脑水肿的作用是通过以下方式实现的:①改善毛细血管通透性,减少或阻止液体外渗。在实验性血管源性脑水肿时,激素能减轻示踪物质向血管外渗出,故可改善血脑屏障的通透性,起到消除脑水肿的作用;②实验证明,激素具有“膜稳定”作用,包括溶酶体膜。可使细胞膜延迟离解,溶酶体(Lysosomes)内各种水解酶延迟释放,从而改善细胞的钠、钾离子主动运
Since the treatment of rheumatoid arthritis with ACTH and adrenal hormones by Hench et al. (1949), more than 30 years of clinical application of corticosteroids have become widespread. The late 50’s for the treatment of brain edema achieved remarkable results. Its anti-brain edema effect is achieved through the following ways: ① improve capillary permeability, reduce or stop the fluid extravasation. In experimental vasogenic brain edema, hormones can reduce traumatic exudation of tracer substances, it can improve the permeability of the blood-brain barrier, play a role in the elimination of cerebral edema; ② experiments show that hormones with “membrane stability ”Role, including lysosomal membranes. Can delay the dissociation of the cell membrane, lysosomes (Lysosomes) a variety of delayed release of hydrolase, thereby improving the cell’s sodium, potassium ion active transport