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应用抗人胃癌单克隆抗体MG7及ABC免疫酶标技术,检测了胃癌相关抗原在110例手术切除胃癌标本及343例胃粘膜活检肠化标本的表达。应用粘液组化方法将肠化分为Ⅰ、Ⅱ和Ⅲ型。110例胃癌中,有92例(83.6％)MG7染色阳性。在不同类型肠化中,Ⅲ型肠化中MG7相应抗原的阳性率(46.7％)显著高于Ⅱ型(25.6％)和Ⅰ型肠化(18.6％)(P<0.01)。结果表明,Ⅲ型肠化与胃癌的发生有密切关系,应作为癌前病变对待;单克隆抗体MG7对筛选肠化患者中胃癌高危病例可能有重要价值。
Using anti-human gastric cancer monoclonal antibody MG7 and ABC immunoenzyme labeling technology, the expression of gastric cancer-associated antigen was detected in 110 cases of surgically resected gastric cancer and 343 cases of gastric mucosal biopsy of intestinal metaplasia. The intestinal metaplasia was divided into type I, II and III by mucus histochemistry. In 110 cases of gastric cancer, 92 cases (83.6%) were positive for MG7 staining. In different types of intestinal metaplasia, the positive rate of MG7 corresponding antigen (46.7%) in type III intestinal metaplasia was significantly higher than that of type II (25.6%) and type I intestinal metaplasia (18.6%) (P<0.01). The results showed that type III intestinal metastasis is closely related to the occurrence of gastric cancer and should be treated as a precancerous lesion; monoclonal antibody MG7 may be of great value in screening for high-risk gastric cancer in patients with intestinal metaplasia.