论文部分内容阅读
目的观察缬沙坦联合氨氯地平治疗社区老年原发性高血压合并糖尿病的临床效果。方法将120例社区老年原发性高血压合并糖尿病患者随机分为观察组与对照组,每组60例。以常规降糖药为基础,2组患者均使用缬沙坦治疗,观察组加用氨氯地平治疗,对照组加用硝苯地平缓释片治疗,对比2组收缩压(SBP)、舒张压(DBP)下降幅度及治疗后餐后2h血糖(2h PG)、空腹血糖(FBG)、空腹胰岛素水平(FINS)及胰岛素敏感指数(ISI)。结果观察组血压下降幅度大于对照组,差异有统计学意义(P<0.05)。观察组患者治疗后2h PG、FBG、FINS以及ISI水平均优于对照组,差异均有统计学意义(P<0.05)。结论缬沙坦联合氨氯地平治疗社区老年原发性高血压合并2型糖尿病患者,效果显著,值得进一步推广使用。
Objective To observe the clinical effect of valsartan combined with amlodipine in the treatment of elderly essential hypertension complicated with diabetes in community. Methods A total of 120 elderly patients with essential hypertension complicated with diabetes were randomly divided into observation group and control group, with 60 cases in each group. On the basis of conventional hypoglycemic agents, valsartan was used in both groups, amlodipine in the observation group and nifedipine in the control group. Compared with SBP and DBP, (DBP), postprandial 2h PG, fasting blood glucose (FBG), fasting insulin (FINS) and insulin sensitivity index (ISI) after treatment were measured. Results The decrease of blood pressure in the observation group was greater than that in the control group, with significant difference (P <0.05). The levels of PG, FBG, FINS and ISI in observation group were better than those in control group at 2h after treatment, and the differences were statistically significant (P <0.05). Conclusion Valsartan combined with amlodipine treatment of elderly patients with essential hypertension in patients with type 2 diabetes, the effect is significant and worthy of further promotion and use.