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目的:观察短期阿托伐他汀治疗对高胆固醇血症的冠心病患者血管内皮功能的影响。方法:78例高胆固醇血症患者每日口服阿托伐他汀共8周,服药前后测量患者血清的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和氧化低密度脂蛋白(ox-LDL)以及NO值,并用彩色多普勒超声测定反应性充血时肱动脉内径的变化。结果:高胆固醇血症患者经阿托伐他汀8周治疗后,血清的TC、TG、LDL-C和ox-LDL明显下降,血清的HDL-C以及NO值明显增加,反应性充血时肱动脉内径扩张程度明显增加,这些与治疗前相比有明显差异。结论:阿托伐他汀治疗能使高胆固醇血症的冠心病患者血脂改变,NO值增加,血管内皮功能改善。
Objective: To observe the effects of short-term atorvastatin treatment on the vascular endothelial function in patients with hypercholesterolemia and coronary heart disease. Methods: A total of 78 patients with hypercholesterolemia were treated with atorvastatin orally for 8 weeks before and after treatment. The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) HDL-C, ox-LDL and NO were measured. The changes of the diameter of brachial artery during reactive hyperemia were measured by color Doppler ultrasonography. Results: After treatment with atorvastatin for 8 weeks, the levels of TC, TG, LDL-C and ox-LDL in serum of patients with hypercholesterolemia were significantly decreased, the levels of serum HDL-C and NO were significantly increased, and the brachial artery Significantly increased the degree of internal diameter expansion, these were significantly different from before treatment. Conclusion: Atorvastatin treatment can make hypercholesterolemia in patients with coronary heart disease, blood lipids, NO increased, endothelial function improved.