论文部分内容阅读
目的探讨蛛网膜下腔出血后脑血管发生病理学的变化及通过药物(前列地尔)治疗后脑血管痉挛的抑制作用。方法将本组动物实验分为三组:对照组、蛛网膜下腔出血组及蛛网膜下腔出血后药物治疗组,三组在光学显微镜及电镜下观察大脑中动脉血管内膜、中膜及血管内径、血管壁厚度。结果蛛网膜下腔出血后药物治疗组对血管病理学及血管形态学的改变:明显减轻蛛网膜下腔出血后所致的脑血管痉挛程度并随之减轻血管壁发生的病理学改变,血管内径及血管壁的厚度得到明显改善。结论前列地尔可有效缓解蛛网膜下腔出血后脑血管痉挛。
Objective To investigate the pathological changes of cerebrovascular after subarachnoid hemorrhage and the inhibitory effect of cerebral vasospasm after treatment with drugs (alprostadil). Methods The animal experiments were divided into three groups: control group, subarachnoid hemorrhage group and drug treatment group after subarachnoid hemorrhage. The three groups were observed under light microscope and electron microscope in the intima, Blood vessel diameter, blood vessel wall thickness. Results After the subarachnoid hemorrhage, the changes of vascular pathology and vascular morphology in the drug-treated group significantly reduced the degree of cerebral vasospasm caused by subarachnoid hemorrhage and reduced the pathological changes of vascular wall, And the thickness of the vascular wall has been significantly improved. Conclusion Alprostadil can effectively relieve cerebral vasospasm after subarachnoid hemorrhage.