SPIN-LABELED ANTITUMOR DERIVATIVES OF PODOPHYLLOTOXIN

• 作 者: 陈耀祖 张长久 田暄
• 机 构: Department of Chemistry, Lanzhou University,Department of Chemistry, Lanzhou University,Department o
• 出 处: Science in China,Ser.B
• 发表日期: 1987年10期
• 关键词: parent labeled antitumor organs SPIN linearly toxicity tetramethyl marked benzen

Three spin-labeled antitumor derivatives of podophyllotoxin, containing an iminoxyl radical,have been synthesized.Preliminary pharmacological tests showed that these derivatives have significant antitumor activity in several experimental tumor systems with a marked decrease in toxicity compared with the parent compound.The relative intensities of ESR signals of these spin-labeled compounds were linearly proportional to their concentrations, the levels of the agent in blood and organs of mice or rabbits can be measured via ESR spectrometry.

Three spin-labeled antitumor derivatives of podophyllotoxin, containing an iminoxyl radical, have been synthesized. Preliminary pharmacological tests showed those derivatives have significant antitumor activity in several experimental tumor systems with a marked decrease in toxicity compared with the parent compound. The relative intensities of ESR signals of these spin-labeled compounds were linearly proportional to their concentrations, the levels of the agent in blood and organs of mice or rabbits can be measured via ESR spectrometry.