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甘露醇广泛用于降低颅内压,且对缺血性、肾毒性急性肾功能衰竭(ARF)具有保护作用,但这种似乎无害的制剂可造成 ARF 则鲜为人知。本文报道①组,甘露醇所致的 ARF 8例,其中脑血管意外7例,脑外伤1例而使用甘露醇;②组,基础肾功能正常7例;③组,原有肾功能损害14例。结果①组:年龄62±15岁,甘露醇每日剂量189±64g,总量626±270g。使用天数3.5±1.5天,少尿性 ARF 发生在用药后3.5±1.1天,高峰血清肌酐浓度为5.7±2.7mg/dl,停药后肾损害持续7～10
Mannitol is widely used to reduce intracranial pressure and has protective effects on ischemic, nephrotoxic, acute renal failure (ARF), but this seemingly innocuous formulation can make ARF less well known. This article reported ① group, 8 cases of ARF caused by mannitol, including cerebrovascular accident in 7 cases, brain injury in 1 case and the use of mannitol; ② group, the basic renal function was normal in 7 cases; ③ group, the original renal dysfunction in 14 cases . Results ① group: age 62 ± 15 years, mannitol daily dose 189 ± 64g, the total amount of 626 ± 270g. The use of days 3.5 ± 1.5 days, ARU oligoalbuminum occurred 3.5 ± 1.1 days after treatment, the peak serum creatinine concentration of 5.7 ± 2.7mg / dl, after stopping the renal damage lasting 7 to 10