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Dover在1971年曾报告用水杨酸磺胺吡啶(Salazopyrin)治疗硬皮病和同类疾病有效。起始口服剂量每日1～6克,维持剂量每日0.25～7克,疗程1～35个月。在经治的19例患者中,11例进行性全身性硬化病均获主观症状改善,另外6名有各种症状的病例也有好转。18例有皮损的患者皮肤均趋软化。其他疗效包括关节动度增加、毛发生长和色素沉着减轻。副作用有发烧、皮疹、恶心、白细胞减少、白细胞增加和血小板血症等,但均不严重,减药后即消失。
Dover reported in 1971 that treatment of scleroderma and congee diseases with salicylate salicylate (Salazopyrin) was effective. The initial oral dose of 1 to 6 grams daily to maintain the dose of 0.25 to 7 grams per day for 1 to 35 months. Among the 19 patients who were treated, subjective symptoms improved in 11 patients with progressive systemic sclerosis, and the other 6 patients with various symptoms also improved. 18 cases of patients with skin lesions tend to soften the skin. Other effects include increased joint mobility, hair growth and reduced pigmentation. Side effects are fever, rash, nausea, leukopenia, leukocytosis and thrombocytopenia, etc., but are not serious, after the disappearance of the drug.