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目的用自己设计的胃粘膜活检组织切片美蓝染色法检查Hp,研究Hp感染与消化不良等症状的关系,及Hp感染与胃粘膜慢性炎症、消化性溃疡等病理改变的关系。方法对32例无症状者及476例有消化不良等症状者在进行内镜检查及常规病理活检的同时,对组织切片行美蓝染色检查Hp,对无症状组及各疾病组的Hp检出率进行比较。结果美蓝染色方法简单,效果好。Hp感染在无症状人群中达43.7%,其中胃粘膜活检有慢性炎症改变者Hp检诊达85.7%;胃粘膜病理活检正常者Hp检出率为6.3%。慢性胃炎及消化性溃疡的Hp检出率分别为54.5%及48.9%。结论 Hp感染与镜下胃粘膜炎症改变相关而不一定有消化不良症状。Hp感染可引起慢性胃炎、消化性溃疡等胃粘膜病变。
Objective To study the relationship between Hp infection and indigestion, Hp infection and gastric mucosal chronic inflammation, peptic ulcer and other pathological changes by using its own design of gastric mucosa biopsy tissue section methylene blue staining Hp. Methods 32 cases of asymptomatic and 476 cases of dyspepsia and other symptoms in the endoscopy and routine biopsy at the same time, the tissue sections were stained with methylene blue check Hp, asymptomatic group and the disease group Hp detection Rate for comparison. Results methylene blue staining method is simple, good effect. Hp infection in asymptomatic population of up to 43.7%, including gastric mucosal biopsy with chronic inflammation of Hp test up to 85.7%; gastric mucosa biopsy normal Hp detection rate of 6.3%. Chronic gastritis and peptic ulcer Hp detection rates were 54.5% and 48.9%. Conclusions Hp infection is related to the change of microscopic gastric mucosal inflammation but not necessarily dyspeptic symptoms. Hp infection can cause chronic gastritis, peptic ulcer and other gastric mucosal lesions.