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目的探讨贝那普利联合阿托伐他汀钙治疗原发性高血压伴高血脂的临床价值。方法选择原发高血压伴高血脂患者70例,随机分为观察组和对照组,观察组患者应用阿托伐他汀钙及盐酸贝那普利,对照组患者应用盐酸贝那普利。比较两组患者治疗效果。结果 (1)与治疗前相比,两组患者收缩压及舒张压于治疗后均显著降低(P﹤0.05)。治疗后,观察组患者收缩压及舒张压均显著低于对照组(P﹤0.05)。(2)与治疗前相比,观察组患者TG、TC及LDL-C水平均明显降低,HDL-C水平显著升高(P﹤0.05)。治疗后,观察组患者TG、TC及LDL-C水平明显低于对照组,HDL-C水平显著高于对照组(P﹤0.05)。(3)与治疗前相比,观察组患者CRP、U-pro水平均明显降低(P﹤0.05)。治疗后,观察组患者CRP、U-pro水平明显低于对照组(P﹤0.05)。结论在原发性高血压伴高血脂的治疗中,贝那普利联合阿托伐他汀钙具有良好的效果,具有很高的临床应用价值。
Objective To investigate the clinical value of benazepril combined with atorvastatin calcium in treating essential hypertension with hyperlipidemia. Methods Seventy patients with primary hypertension and hyperlipidemia were randomly divided into observation group and control group. Atorvastatin calcium and benazepril hydrochloride were used in observation group and benazepril hydrochloride in control group. Compare the treatment effect of two groups of patients. Results (1) Compared with those before treatment, the systolic and diastolic blood pressures were significantly decreased in both groups after treatment (P <0.05). After treatment, systolic blood pressure and diastolic blood pressure in the observation group were significantly lower than those in the control group (P <0.05). (2) The levels of TG, TC and LDL-C in the observation group were significantly lower than those before treatment, and the level of HDL-C was significantly increased (P <0.05). After treatment, the levels of TG, TC and LDL-C in the observation group were significantly lower than those in the control group, and the levels of HDL-C in the observation group were significantly higher than those in the control group (P <0.05). (3) The CRP and U-pro levels in observation group were significantly lower than those before treatment (P <0.05). After treatment, CRP and U-pro levels in the observation group were significantly lower than those in the control group (P <0.05). Conclusion In the treatment of essential hypertension with hyperlipidemia, benazepril combined with atorvastatin calcium has good effect and has high clinical value.