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脂联素是所有脂肪细胞因子中惟一的负性调节激素,具有降糖、增加胰岛素敏感性和抗炎等作用。脂联素的这些效应必须通过其受体AdipoRl和AdipoR2介导来完成。脂联素可能通过抑制转化生长因子β、肿瘤坏死因子α等的作用及减少α平滑肌肌动蛋白的表达等机制维持肝星形细胞(HSC)静息状态、抑制HSC的活化及其增殖与迁移,并促进活化HSC凋亡,从而抑制肝纤维化发生、发展。脂联素与慢性丙型肝炎的病毒复制水平与基因型相关,对脂联素及慢性丙型肝炎关系的研究可为慢性丙型肝炎诊治提供新的思路。
Adiponectin is the only negative regulator of all adipocytokines, with hypoglycemic effects, increased insulin sensitivity and anti-inflammatory effects. These effects of adiponectin must be mediated through its receptors AdipoRl and AdipoR2. Adiponectin may maintain the resting status of hepatic stellate cells (HSC), inhibit the activation of HSC and its proliferation and migration by inhibiting the effects of transforming growth factor-β, tumor necrosis factor-α, and reducing the expression of α-smooth muscle actin , And promote the activation of HSC apoptosis, thereby inhibiting the occurrence and development of liver fibrosis. Adiponectin and chronic hepatitis C virus replication level and genotypes, the study of adiponectin and chronic hepatitis C can provide a new idea for the diagnosis and treatment of chronic hepatitis C.